Lipids driving protein structure? Evolutionary adaptations in Kir channels
نویسندگان
چکیده
منابع مشابه
Lipids driving protein structure? Evolutionary adaptations in Kir channels.
Many eukaryotic channels, transporters and receptors are activated by phosphatidyl inositol bisphosphate (PIP(2)) in the membrane, and every member of the eukaryotic inward rectifier potassium (Kir) channel family requires membrane PIP(2) for activity. In contrast, a bacterial homolog (KirBac1.1) is specifically inhibited by PIP(2). We speculate that a key evolutionary adaptation in eukaryotic ...
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ژورنال
عنوان ژورنال: Channels
سال: 2010
ISSN: 1933-6950,1933-6969
DOI: 10.4161/chan.4.3.12129